Understanding how Toxoplasma survives in human cells
Restriction of Toxoplasma growth in human cells
This study is looking at how the Toxoplasma gondii parasite, which can cause illness, survives in our bodies and how our immune system tries to fight it off, with the hope of finding better treatments for people who are at risk of getting really sick from it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10984987 on NIH RePORTER |
What this research studies
This research investigates how the Toxoplasma gondii parasite survives and grows within human cells, particularly focusing on the immune responses triggered by cytokines like TNFα. The study aims to uncover the mechanisms by which human immune cells can detect and eliminate Toxoplasma, as well as how the parasite evades these defenses. By using primary human cells in laboratory settings, researchers will explore the interactions between the parasite and the immune system, which could lead to new treatments for those at risk of severe toxoplasmosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are immunocompromised or those who may be at risk for severe toxoplasmosis, such as pregnant women or individuals with HIV/AIDS.
Not a fit: Patients who are not at risk for toxoplasmosis or those with a fully functioning immune system may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that reduce the health impacts of toxoplasmosis in vulnerable populations.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to Toxoplasma in animal models, but this specific approach in human cells is relatively novel.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Saeij, Jeroen — University of California at Davis
- Study coordinator: Saeij, Jeroen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.