Understanding how toxic substances affect brain cell development and function
Toxicant Induced dysregulation of parvalbumin interneuron development and function
['FUNDING_R01'] · BROWN UNIVERSITY · NIH-10745909
This study is looking at how being around harmful substances while the brain is developing can affect certain brain cells that are important for healthy brain function, and it's using zebrafish to help find ways to better understand and possibly prevent conditions like Alzheimer's Disease in people.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BROWN UNIVERSITY (nih funded) |
| Locations | 1 site (PROVIDENCE, UNITED STATES) |
| Trial ID | NIH-10745909 on ClinicalTrials.gov |
What this research studies
This research investigates how exposure to toxic substances during critical developmental periods can disrupt the growth and function of specific brain cells known as parvalbumin interneurons. By using advanced imaging techniques in zebrafish, the study aims to uncover the molecular mechanisms that lead to neurological diseases and psychiatric disorders, including Alzheimer's Disease. The researchers are developing genetic tools to visualize and manipulate these brain cells, which could provide insights into how to prevent or treat these conditions in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for neurological diseases or psychiatric disorders, particularly those with a family history of conditions like Alzheimer's Disease.
Not a fit: Patients with neurological or psychiatric disorders that are not influenced by toxicant exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating neurological diseases and psychiatric disorders.
How similar studies have performed: Other research has shown success in using animal models to understand the effects of toxicant exposure on brain development, suggesting that this approach could yield valuable insights.
Where this research is happening
PROVIDENCE, UNITED STATES
- BROWN UNIVERSITY — PROVIDENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PLAVICKI, JESSICA SUSAN — BROWN UNIVERSITY
- Study coordinator: PLAVICKI, JESSICA SUSAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome