Understanding how toxic lipids cause liver inflammation and portal hypertension
Lipotoxicity and Liver Inflammation
This study is looking at how harmful fats can cause liver inflammation and high blood pressure in the liver, especially for people with a liver condition called MASH, to find new ways to help treat these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11074536 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which toxic lipids lead to liver inflammation and portal hypertension, particularly in patients with metabolic dysfunction-associated steatohepatitis (MASH). The study focuses on liver sinusoidal endothelial cells (LSECs) and how their dysfunction contributes to these conditions. By examining the signaling pathways and molecular mediators involved, the research aims to uncover the role of specific kinases and adhesion molecules in the disease process. Patients may benefit from insights that could lead to new therapeutic strategies targeting these pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with metabolic dysfunction-associated steatohepatitis (MASH) who are experiencing liver inflammation or portal hypertension.
Not a fit: Patients without metabolic dysfunction or those who do not have liver-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for liver inflammation and portal hypertension, improving outcomes for patients with metabolic liver diseases.
How similar studies have performed: Other research has shown promising results in understanding liver inflammation mechanisms, but this specific approach focusing on LSEC endotheliopathy is relatively novel.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Ibrahim, Samar — Mayo Clinic Rochester
- Study coordinator: Ibrahim, Samar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.