Understanding how toxic fatty acids affect muscle function and metabolism
Determining the Biological Effects of Mitochondrial Acyl Toxicity
['FUNDING_R01'] · EAST CAROLINA UNIVERSITY · NIH-10655498
This study is looking at how certain harmful substances that build up in the body during conditions like obesity and diabetes can affect muscle function and energy production, using special mice to help understand the problem better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EAST CAROLINA UNIVERSITY (nih funded) |
| Locations | 1 site (GREENVILLE, UNITED STATES) |
| Trial ID | NIH-10655498 on ClinicalTrials.gov |
What this research studies
This research investigates the harmful effects of long-chain acylcarnitines (LCACs), which accumulate during metabolic stress and diseases like obesity and diabetes. Using a specially developed mouse model, researchers will explore how these toxic metabolites disrupt essential processes such as insulin signaling and calcium balance in muscle cells. The study aims to clarify the mechanisms behind LCAC toxicity and its impact on muscle performance and mitochondrial function. By examining different mouse models, the research seeks to provide insights into the physiological consequences of LCAC accumulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from obesity or diabetes, particularly those experiencing muscle-related complications.
Not a fit: Patients without metabolic disorders or those not experiencing muscle dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating metabolic diseases by targeting the harmful effects of fatty acid accumulation.
How similar studies have performed: While the specific approach of using a mouse model for LCAC accumulation is novel, related research has shown promising results in understanding metabolic dysfunctions in similar contexts.
Where this research is happening
GREENVILLE, UNITED STATES
- EAST CAROLINA UNIVERSITY — GREENVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ELLIS, JESSICA M — EAST CAROLINA UNIVERSITY
- Study coordinator: ELLIS, JESSICA M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.