Understanding how Tox influences exhausted CD8 T cells in chronic infections and cancer
Temporal control of differentiation and epigenetics of Exhausted CD8 T cells by Tox
This study is looking at how a protein called Tox affects tired immune cells, which are important for fighting long-lasting infections and cancer, to find new ways to help these cells work better again for people dealing with these health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10913374 on NIH RePORTER |
What this research studies
This research investigates the role of Tox in the differentiation and epigenetic regulation of exhausted CD8 T cells, which are crucial for controlling chronic infections and cancer. By examining how Tox affects the chromatin landscape and functionality of these cells, the study aims to uncover new therapeutic strategies to reinvigorate exhausted T cells. The approach includes manipulating Tox levels to observe changes in T cell behavior and potential recovery of their immune functions. This could lead to improved treatments for patients suffering from chronic infections and cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with chronic infections or cancer who exhibit T cell exhaustion.
Not a fit: Patients with acute infections or those whose immune systems are not significantly affected by T cell exhaustion may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies that restore the immune response in patients with chronic infections and cancer.
How similar studies have performed: Previous research has shown promising results in targeting T cell exhaustion, but the specific approach of manipulating Tox is relatively novel and untested.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Wherry, E. John — University of Pennsylvania
- Study coordinator: Wherry, E. John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.