Understanding how tooth enamel forms and its defects
Enamel atlas: systems-level amelogenesis tools at multiple scales
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10670353
This study is looking into how tooth enamel forms and what can go wrong, using special tools and mouse models to help find better treatments for people with conditions like amelogenesis imperfecta that affect their enamel.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10670353 on ClinicalTrials.gov |
What this research studies
This research investigates the complex process of amelogenesis, which is how tooth enamel develops. It aims to create advanced tools and models to better understand the genetic and biological factors involved in enamel formation and defects. By utilizing innovative genetic techniques and materials characterization methods, the research team will develop new mouse models that can help identify the mechanisms behind enamel defects. This could lead to improved treatments for conditions like amelogenesis imperfecta, which affects the quality of tooth enamel.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with enamel defects, such as those diagnosed with amelogenesis imperfecta.
Not a fit: Patients without enamel defects or those not affected by genetic conditions related to amelogenesis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with enamel defects.
How similar studies have performed: Other research has shown promise in using genetic models to study enamel formation, indicating that this approach could yield valuable insights.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KLEIN, OPHIR D — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: KLEIN, OPHIR D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.