Understanding how Tomosyn-1 affects insulin release from pancreatic cells
The role of Tomosyn-1 in regulating insulin secretion from pancreatic beta-cells
['FUNDING_OTHER'] · UNIVERSITY OF ALABAMA AT BIRMINGHAM · NIH-11091685
This study is looking at a protein called Tomosyn-1 to see if changing its activity can help people with type 2 diabetes and prediabetes produce more insulin, which is important for managing blood sugar levels.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ALABAMA AT BIRMINGHAM (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-11091685 on ClinicalTrials.gov |
What this research studies
This research investigates the role of Tomosyn-1, a protein that inhibits insulin secretion from pancreatic beta-cells, in the context of type 2 diabetes (T2D) and prediabetes. The study aims to understand how manipulating Tomosyn-1 can enhance insulin secretion, particularly in individuals with impaired glucose tolerance. By examining the mechanisms of insulin granule fusion and the formation of SNARE complexes, researchers hope to identify potential therapeutic targets for improving insulin release. The research involves both animal models and human islet cells to explore the effects of Tomosyn-1 on insulin secretion.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with prediabetes or type 2 diabetes, particularly those experiencing impaired glucose tolerance.
Not a fit: Patients without any form of diabetes or those with type 1 diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve insulin secretion and help manage or prevent type 2 diabetes.
How similar studies have performed: Previous research has shown promising results in manipulating similar proteins to enhance insulin secretion, indicating potential for success in this approach.
Where this research is happening
BIRMINGHAM, UNITED STATES
- UNIVERSITY OF ALABAMA AT BIRMINGHAM — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BHATNAGAR, SUSHANT — UNIVERSITY OF ALABAMA AT BIRMINGHAM
- Study coordinator: BHATNAGAR, SUSHANT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus