Understanding how to use genetic information to fight viral infections
A functional evolutionary genetic approach to combat viral infection
This study is looking at how the immune systems of different mammals, like primates and bats, fight off viruses to find special proteins that could help create new treatments for viral infections in humans.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10891465 on NIH RePORTER |
What this research studies
This research investigates how certain mammals' immune systems respond to viral infections, particularly focusing on the interferon response, which activates genes that help combat viruses. By studying the genetic makeup of various mammals, including primates and bats, the project aims to identify unique antiviral proteins that could be effective against human viruses. The research employs advanced genetic screening techniques on primary cell cultures from different mammalian species to discover and validate these antiviral genes. Ultimately, the goal is to harness these findings to develop new treatments for viral infections that currently lack targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of viral infections, particularly those affected by Ebola or influenza.
Not a fit: Patients with viral infections that are not related to the viruses being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel antiviral treatments for diseases like Ebola and influenza.
How similar studies have performed: Other research has shown promise in using genetic approaches to understand and combat viral infections, indicating that this approach could be effective.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Schoggins, John W. — Ut Southwestern Medical Center
- Study coordinator: Schoggins, John W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.