Understanding how to stabilize stem cells for better medical use
Official title: Resolving epigenetic instability during pluripotent state transitions: a roadmap for exploiting the biomedical potential of dynamic human stem cell states
Funded at Washington University · NIH-11075880 · Data updated 2026-11-12
This study is looking at ways to make better stem cells that can turn into different types of cells in the body, which could help create new treatments for diseases and improve personalized medicine for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $449,395 |
| NIH project number | 5R35GM153439-02 |
| Project ID | NIH-11075880 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with conditions that could be treated using stem cell therapies, such as degenerative diseases or genetic disorders.
✕Less likely to help
Patients who are not candidates for stem cell therapies or those with conditions unrelated to stem cell applications may not receive benefits from this research.
What this research studies
This research focuses on improving the quality of human pluripotent stem cells (hPSCs) by addressing the challenges of epigenetic instability during their development. The researchers aim to derive 'naïve' hPSCs that closely resemble the early-stage cells found in embryos, which have greater potential for differentiation into various cell types. By investigating the mechanisms behind epigenetic changes, the study seeks to create more reliable stem cell lines that can be used for modeling human diseases and developing new therapies. Patients may benefit from advancements in regenerative medicine and personalized treatments derived from these improved stem cells.
Why it matters
Potential benefit: If successful, this research could lead to more effective stem cell therapies for a variety of diseases and conditions.
How similar studies have gone: Previous research has shown promise in stabilizing stem cells, but this approach aims to address specific epigenetic challenges that have not been fully explored.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Theunissen, Thorold — Washington University
- Study coordinator: Theunissen, Thorold
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.