Understanding how to repair heart valve endothelial cells
Delineating the mechanisms underlying heart valve endothelial repair
['FUNDING_R01'] · MEDICAL COLLEGE OF WISCONSIN · NIH-11030717
This study is looking into how heart valve cells heal, especially for people with a condition called valvular aortic stenosis, to find out why some patients don’t do well after a common treatment called balloon valvuloplasty, with the hope of discovering ways to help improve heart valve health and patient recovery.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL COLLEGE OF WISCONSIN (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-11030717 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind the repair of endothelial cells in heart valves, particularly focusing on patients with valvular aortic stenosis. It aims to understand why some patients experience poor outcomes after balloon valvuloplasty, a common treatment for this condition. By studying the injury and dysfunction of valve endothelium, the research seeks to identify ways to restore endothelial function, which could improve the health of the heart valve and overall patient outcomes. The approach includes both animal models and human tissue studies to gather comprehensive data on endothelial integrity and its role in valve pathology.
Who could benefit from this research
Good fit: Ideal candidates for this research include infants and young children diagnosed with valvular aortic stenosis who are undergoing balloon valvuloplasty.
Not a fit: Patients with heart valve conditions unrelated to aortic stenosis or those who have already undergone surgical interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with heart valve disorders, potentially reducing the need for surgical interventions.
How similar studies have performed: Previous studies have shown that understanding endothelial function can lead to significant advancements in treating heart valve diseases, suggesting that this research could build on established findings.
Where this research is happening
MILWAUKEE, UNITED STATES
- MEDICAL COLLEGE OF WISCONSIN — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LINCOLN, JOY — MEDICAL COLLEGE OF WISCONSIN
- Study coordinator: LINCOLN, JOY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Aortic Injury, cardiac valve disease, cardiac valve disorder