Understanding how to repair heart muscle after injury
Project 1 - Endogenous and Exogenous Mechanisms that Promote Myocardial Remuscularization
This study is exploring ways to help your heart heal after a heart attack by looking at both natural body processes and special patches that can encourage new heart cells to grow and repair the damage.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10897866 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that can help regenerate heart muscle cells after a heart attack. It focuses on both natural factors within the body and engineered solutions, such as a bioengineered cardiac muscle patch that can promote the growth of new heart cells. The approach involves using advanced cell lines that can stimulate the heart's own cells to divide and repair the damaged area. By creating a supportive environment that mimics natural heart tissue, the research aims to improve the survival and function of transplanted cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a heart attack and are 21 years or older.
Not a fit: Patients with non-cardiac related health issues or those who have not experienced a heart attack may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve heart recovery and function after a heart attack.
How similar studies have performed: Previous research has shown promise in using similar approaches to regenerate heart tissue, indicating potential for success in this area.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Zhang, Jianyi — University of Alabama at Birmingham
- Study coordinator: Zhang, Jianyi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.