Understanding how to regulate dopamine transport in the brain
Official title: Regulating dopamine transport through allosteric modulation - Functional and Behavioral Studies
Funded at Drexel University · NIH-11191426 · Data updated 2026-11-12
This study is looking at how certain proteins in the brain that help manage dopamine levels can be adjusted to improve treatments for conditions like ADHD, depression, and anxiety, and it hopes to find new ways to help people feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Drexel University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 15, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $658,497 |
| NIH project number | 5R01DA057982-02 |
| Project ID | NIH-11191426 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit include individuals with ADHD, depression, anxiety, or those affected by substance abuse.
✕Less likely to help
Patients with conditions unrelated to monoamine neurotransmission or those not experiencing any neurological or addictive disorders may not benefit from this research.
What this research studies
This research investigates the role of plasma-membrane monoamine transporters, particularly focusing on dopamine transporters, in regulating neurotransmission. By exploring a newly discovered allosteric site on these transporters, the study aims to identify compounds that can modulate their activity in innovative ways. This could lead to new therapeutic strategies for treating conditions like ADHD, depression, and anxiety, as well as addressing issues related to drug abuse. Patients may benefit from potential new treatments that target these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapies for neurological disorders and substance abuse issues.
How similar studies have gone: Previous research has shown promise in targeting similar allosteric sites on transporters, indicating a potential for success in this novel approach.
Where this research is happening
-
Drexel University
Philadelphia, United States Active
Researchers
- Principal investigator: Mortensen, Ole Valente — Drexel University
- Study coordinator: Mortensen, Ole Valente
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.