Understanding how to regulate and inhibit a key enzyme involved in cancer metabolism
Metabolic regulation and inhibition of ATP-citrate lyase
This study is looking at a special enzyme called ACLY that helps produce important substances for our body's metabolism, and the researchers want to find ways to block this enzyme to help treat cancer and metabolic disorders in patients who have high levels of ACLY.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11054661 on NIH RePORTER |
What this research studies
This research focuses on ATP-citrate lyase (ACLY), an enzyme that plays a crucial role in producing acetyl-CoA, which is vital for various metabolic processes. The team aims to explore the molecular mechanisms that regulate ACLY and to develop inhibitors that could be used in cancer therapy. By studying how ACLY functions and its modifications in cancer cells, the researchers hope to identify new treatment strategies for patients with metabolic disorders and cancers associated with elevated ACLY activity. The research involves biochemical analyses and biological models to test the effectiveness of these inhibitors.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with metabolic disorders or specific cancers that exhibit elevated ACLY activity.
Not a fit: Patients with cancers or metabolic disorders that do not involve ACLY or its metabolic pathways may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new cancer therapies that target metabolic pathways, potentially improving outcomes for patients with certain types of cancer.
How similar studies have performed: Previous research has shown promise in targeting metabolic pathways in cancer therapy, suggesting that this approach could yield significant advancements.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Marmorstein, Ronen — University of Pennsylvania
- Study coordinator: Marmorstein, Ronen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.