Understanding how to regenerate periodontal tissue
Official title: Cellular and molecular control of periodontal tissue regeneration
Funded at Harvard Medical School · NIH-11129036 · Data updated 2026-11-12
This study is looking at how certain stem cells in your gums can help heal and regenerate the tissue around your teeth, especially when there's inflammation, so that we can create better treatments to keep your gums healthy and prevent tooth loss.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 16, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $557,606 |
| NIH project number | 1R01DE033991-01A1 |
| Project ID | NIH-11129036 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults suffering from periodontal diseases or those at risk of tooth loss due to periodontal tissue damage.
✕Less likely to help
Patients with healthy periodontal tissues or those without any periodontal disease may not receive direct benefits from this research.
What this research studies
This research investigates the mechanisms behind the regeneration of periodontal tissue, which is crucial for maintaining healthy teeth. It focuses on identifying distinct populations of stem cells in the periodontal region and how these cells can be regulated to repair and regenerate damaged tissues. By exploring the effects of inflammation on these stem cells, the research aims to develop strategies for more effective periodontal treatments. Patients may benefit from advancements in therapies that restore periodontal health and prevent tooth loss.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for periodontal diseases, reducing tooth loss and enhancing oral health.
How similar studies have gone: Previous research has shown promise in using stem cell therapies for tissue regeneration, indicating potential success for this approach.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Yang, Yingzi — Harvard Medical School
- Study coordinator: Yang, Yingzi
Related research
Other NIH-funded projects on the same topics.
-
Comparing End-of-Life Care for Older Adults Across Richer Countries
Aims to understand how end-of-life care for older adults with serious illnesses differs in the US compared with other high-income countries.
-
Comparing End-of-Life Care for Older Adults Across Rich Countries
A study compares how end-of-life care is handled for older adults in the US and other high-income countries to identify what might improve care here.
-
Comparing End-of-Life Care for Older Adults in Rich Countries
A large study from Harvard Medical School compares how older adults near the end of life are cared for in the US and other top-income countries to understand differences and improve care.
-
Comparing End-of-Life Care for Older Adults Across Rich Countries
A study using international data to understand how end-of-life care for older adults with poor prognoses differs across five high‑income countries.
-
Comparing End-of-Life Care for Older Adults Across Rich Countries
A research project compares how older adults with serious illnesses receive end-of-life care in the US and other high-income countries to find ways to improve care in the United States.
-
Comparing End-of-Life Care for Older Adults Across Rich Countries
A project compares how older adults near the end of life are cared for in the U.S. and other high-income countries to identify ways to improve care and reduce wasteful spending.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.