Understanding how to reduce kidney inflammation in people with high blood pressure
Control of Renal Inflammation in Hypertension
This study is looking at how long-term kidney inflammation affects people with high blood pressure who don't get better with regular treatments, and it aims to find new ways to help reduce inflammation and lower blood pressure, especially for those with conditions like lupus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11144461 on NIH RePORTER |
What this research studies
This research investigates the role of chronic kidney inflammation in patients with hypertension, particularly those who do not respond to standard treatments. By using a model of systemic lupus erythematosus, a condition known for its inflammatory effects, the study aims to uncover the mechanisms that lead to hypertension. The researchers will explore how enhancing the body's neuro-immunoregulatory systems can help control inflammation and lower blood pressure. Patients may be involved in trials that test new therapeutic strategies aimed at reducing renal inflammation.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with hypertension, especially those who have not responded to existing therapies.
Not a fit: Patients with hypertension that is well-controlled by current medications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for hypertension that are effective for patients who currently have resistant high blood pressure.
How similar studies have performed: Previous research has shown promise in using neuro-immunoregulatory pathways to manage inflammation, suggesting that this approach could be effective.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Mathis, Keisa Williams — Ut Southwestern Medical Center
- Study coordinator: Mathis, Keisa Williams
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.