Understanding how to reactivate mutated p53 in cancer
Mechanisms of mutant p53 reactivation
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-11124774
This research aims to understand how to turn mutated p53, a protein often found in cancer, back into a tumor fighter.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-11124774 on ClinicalTrials.gov |
What this research studies
Many cancers have a mutated p53 protein that not only stops fighting tumors but also helps cancer grow. This project focuses on understanding the exact ways these mutated p53 proteins work and how they might be changed back to their normal, tumor-suppressing form. Researchers are looking for new ways to develop 'corrector drugs' that can bind to the mutated p53 and restore its healthy function. The goal is to overcome past challenges in drug development by gaining a deeper understanding of these mechanisms.
Who could benefit from this research
Good fit: Patients with cancers that express mutated p53, particularly those with mutations at hotspot sites in the p53 DNA binding domain, are the target population for future therapies derived from this work.
Not a fit: Patients whose cancers do not involve p53 mutations or who have other forms of cancer may not directly benefit from this specific research direction.
Why it matters
Potential benefit: If successful, this research could lead to new and more effective drugs that reactivate mutated p53, offering a novel treatment approach for a wide range of cancers.
How similar studies have performed: Developing effective p53 reactivator compounds has been challenging, with limited success in clinical trials, making this a novel and critical area of investigation.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KAISER, PETER — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: KAISER, PETER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.