Understanding how to protect and regenerate nerve cells in the eye
Epigenomic mechanisms regulating RGC survival and axon regeneration
This study is looking at how certain changes in our genes can affect the health and recovery of important eye cells that help us see, especially after injuries or conditions like glaucoma, with the hope of finding new ways to help people keep their vision.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11017041 on NIH RePORTER |
What this research studies
This research investigates the epigenetic factors that influence the survival and regeneration of retinal ganglion cells (RGCs), which are crucial for vision. Using mouse models of optic nerve injury and glaucoma, the study aims to uncover the mechanisms that lead to RGC degeneration and explore potential therapeutic strategies. The research involves advanced techniques in epigenomic profiling to identify how gene expression changes in response to injury, which could inform new treatments for conditions like glaucoma. Patients may benefit from insights that could lead to innovative therapies aimed at preserving vision.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of or currently experiencing vision loss due to glaucoma or other optic nerve injuries.
Not a fit: Patients with vision loss due to non-glaucomatous causes or those who are not experiencing any optic nerve damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help prevent blindness caused by conditions like glaucoma.
How similar studies have performed: Previous research has shown promise in understanding the mechanisms of nerve regeneration, but this specific approach focusing on epigenetic regulation is relatively novel.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Tian, Feng — Beth Israel Deaconess Medical Center
- Study coordinator: Tian, Feng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.