Understanding how to protect against the effects of severe blood loss
A novel protective mechanism in hemorrhagic shock
This study is looking at how blood loss affects recovery in trauma patients, especially focusing on a hormone called irisin that might help improve their healing by making their bodies respond better to insulin.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rhode Island Hospital NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-10828372 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind hemorrhagic shock, a critical condition resulting from severe blood loss that can lead to death or long-term disability. The study focuses on how metabolic disturbances, particularly insulin resistance, affect recovery in trauma patients. By exploring the role of a hormone called irisin, which is secreted by skeletal muscle, the research aims to find ways to improve insulin sensitivity and overall outcomes for patients who have experienced significant bleeding. The approach includes examining the signaling pathways involved in these processes to develop potential therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have experienced severe trauma resulting in significant blood loss.
Not a fit: Patients who have not experienced hemorrhagic shock or trauma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve survival and recovery for patients suffering from hemorrhagic shock.
How similar studies have performed: Previous research has shown promising results in managing metabolic disturbances in trauma patients, suggesting that this approach could be effective.
Where this research is happening
Providence, United States
- Rhode Island Hospital — Providence, United States (Active)
Researchers
- Principal investigator: Zhao, Ting C — Rhode Island Hospital
- Study coordinator: Zhao, Ting C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.