Understanding how to protect against hearing loss from loud noises
Mechanisms of protection from noise-induced hearing loss
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11009948
This study is looking into how certain genes might make some young people more likely to lose their hearing from loud noises, with the goal of finding ways to prevent or treat this kind of hearing loss.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11009948 on ClinicalTrials.gov |
What this research studies
This research investigates the cellular and molecular mechanisms that lead to noise-induced hearing loss (NIHL), which affects a significant number of young people globally. By studying genetic factors and their role in sensitivity to NIHL, the research aims to identify potential therapies for prevention and treatment. The approach includes genetic analysis and mouse models to understand how certain genes, like Prkag2, influence the stability of inner hair cells in the cochlea when exposed to damaging noise levels. This could lead to new strategies for protecting hearing in at-risk populations.
Who could benefit from this research
Good fit: Ideal candidates for this research include young individuals aged 12-35 who are at risk of hearing loss due to noise exposure.
Not a fit: Patients who have already experienced significant hearing loss or those outside the age range of 12-35 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or repair hearing loss caused by noise exposure.
How similar studies have performed: Previous research has shown promise in understanding genetic factors related to hearing loss, making this approach both relevant and potentially impactful.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FRIEDMAN, RICK A — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: FRIEDMAN, RICK A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.