Understanding how to protect against dengue illness in children in Thailand
Defining correlates of protection from dengue illness in a long-term cohort study of multigenerational house-holds in Thailand
This study is looking at how kids' first experiences with dengue viruses affect their immune systems and how well they can fight off future infections, and it's for families in Thailand who want to help us learn more about protecting against dengue and improving vaccines.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project ID | NIH-10885114 on NIH RePORTER |
What this research studies
This research investigates how children's early exposures to dengue viruses influence their immune responses and protection against future infections. By studying a long-term cohort of families in Thailand, the researchers aim to identify key immune markers that indicate protection against dengue. The study involves monitoring and analyzing the health outcomes of children as they experience dengue infections over time, providing valuable insights into vaccine development. Participants will be part of a comprehensive surveillance program that tracks dengue infections and immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years living in areas with high dengue virus transmission in Thailand.
Not a fit: Patients who do not live in dengue-endemic regions or who are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective dengue vaccines that provide better protection for children.
How similar studies have performed: Previous research has shown that understanding immune responses in similar cohorts can lead to significant advancements in vaccine development.
Where this research is happening
Syracuse, United States
- Upstate Medical University — Syracuse, United States (Active)
Researchers
- Principal investigator: Anderson, Kathryn B — Upstate Medical University
- Study coordinator: Anderson, Kathryn B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.