Understanding how to protect against dengue illness in children in Thailand
Official title: Defining correlates of protection from dengue illness in a long-term cohort study of multigenerational house-holds in Thailand
Funded at Upstate Medical University · NIH-10885114 · Data updated 2026-11-12
This study is looking at how kids' first experiences with dengue viruses affect their immune systems and how well they can fight off future infections, and it's for families in Thailand who want to help us learn more about protecting against dengue and improving vaccines.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project start | July 10, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $671,876 |
| NIH project number | 5R01AI175941-02 |
| Project ID | NIH-10885114 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years living in areas with high dengue virus transmission in Thailand.
✕Less likely to help
Patients who do not live in dengue-endemic regions or who are older than 11 years may not benefit from this research.
What this research studies
This research investigates how children's early exposures to dengue viruses influence their immune responses and protection against future infections. By studying a long-term cohort of families in Thailand, the researchers aim to identify key immune markers that indicate protection against dengue. The study involves monitoring and analyzing the health outcomes of children as they experience dengue infections over time, providing valuable insights into vaccine development. Participants will be part of a comprehensive surveillance program that tracks dengue infections and immune responses.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective dengue vaccines that provide better protection for children.
How similar studies have gone: Previous research has shown that understanding immune responses in similar cohorts can lead to significant advancements in vaccine development.
Where this research is happening
-
Upstate Medical University
Syracuse, United States Active
Researchers
- Principal investigator: Anderson, Kathryn B — Upstate Medical University
- Study coordinator: Anderson, Kathryn B
Related research
Other NIH-funded projects on the same topics.
-
Immune responses linked to severe dengue in children (primary infection)
This grant studies why some kids get very sick from their first dengue infection and how their immune system reacts differently from secondary infections.
-
Phase 2b trial of dengue vaccines TAK-003 and Butantan-DV to boost lasting, broad antibody protection
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Selective GAK inhibitors to fight dengue, VEEV and other emerging viral infections
A Stanford team is testing new, selective inhibitors of GAK to block how certain viruses enter and exit cells, with the goal of a broad antiviral approach that could help people exposed to dengue, VEEV, and similar infections.
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Defining immune markers predicting protection against dengue in a long-term family study in Thailand
This grant looks at how antibodies develop to protect against dengue in children from a long-running family cohort in Thailand, with the goal of identifying immune signs that predict protection across multiple dengue serotypes.
-
Understanding dengue protection in children from a long-term Thai family cohort
A long-term study in Thailand follows families to understand how early exposures to dengue shape protection and illness risk for children as they encounter the virus over time.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.