Understanding how to promote nerve cell growth and survival after injury
Deciphering the Transcriptional Regulatory Network Controlling RGC Axon Growth to Promote RGC Axon Regeneration and Cell Survival after Axonal Injury
This study is looking at how nerve cells in the eye can grow back after being hurt, and it aims to find out what helps them heal better, which could lead to new treatments for people with nerve injuries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11037999 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that control the growth and regeneration of nerve cells, specifically retinal ganglion cells (RGCs), after they have been damaged. By analyzing gene expression and regulatory networks at different developmental stages, the study aims to identify key factors that influence the ability of these cells to regenerate their axons. The approach involves advanced techniques like RNA sequencing and ATAC sequencing to gain insights into the genetic controls that could enhance nerve repair. Patients with nerve injuries may benefit from the findings that could lead to new treatments for restoring nerve function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced axonal injuries, particularly those affecting the optic nerve.
Not a fit: Patients with non-axonal injuries or conditions unrelated to nerve regeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that enhance nerve regeneration and improve recovery from nerve injuries.
How similar studies have performed: Previous research has shown promising results in enhancing nerve regeneration through similar genetic and molecular approaches, indicating potential for success in this area.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Wang, Xuewei — University of South Florida
- Study coordinator: Wang, Xuewei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.