Understanding how to promote myelin production in the brain
Official title: Molecular Mechanisms of Oligodendrocyte Myelination and remyelination
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11108286 · Data updated 2026-11-12
This study is looking at how to help the brain repair myelin, the protective covering around nerves, which is important for people with conditions like multiple sclerosis, by finding ways to boost the cells that make myelin and discovering new treatments that could improve their nerve function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | June 15, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $614,009 |
| NIH project number | 1R01NS142389-01 |
| Project ID | NIH-11108286 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with demyelinating diseases such as multiple sclerosis.
✕Less likely to help
Patients with conditions unrelated to myelin production or repair may not benefit from this research.
What this research studies
This research investigates the mechanisms behind myelin production and repair in the central nervous system, particularly focusing on oligodendrocytes, the cells responsible for myelination. The study aims to identify factors that enhance myelin production and overcome barriers that inhibit this process, especially in conditions like multiple sclerosis. By utilizing epigenetic reprogramming and screening for compounds that stimulate myelin production, the research seeks to develop effective strategies for improving myelin repair in patients with demyelinating diseases. Patients may benefit from insights that could lead to new treatments aimed at restoring myelin and improving neurological function.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance myelin repair, potentially improving outcomes for patients with demyelinating diseases.
How similar studies have gone: Previous research has shown promise in using epigenetic approaches to enhance myelin production, indicating potential for success in this area.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Lu, Qing R — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Lu, Qing R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.