Understanding how to prevent harmful sodium currents in heart conditions
Official title: Mechanism-inspired Strategies to Prevent Pathogenic Late Na Current in Cardiac Arrhythmias
Funded at Columbia University Health Sciences · NIH-10988288 · Data updated 2026-11-12
This study is looking at how certain channels in the heart can cause problems like irregular heartbeats and heart failure, and it's for anyone interested in new ways to help manage these issues by exploring a special protein that could lead to better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 17, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $499,898 |
| NIH project number | 5R01HL163576-03 |
| Project ID | NIH-10988288 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 who have been diagnosed with cardiac arrhythmias or related heart conditions.
✕Less likely to help
Patients with non-cardiac related health issues or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the role of NaV1.5 channels in heart function and how their dysfunction can lead to serious conditions like cardiac arrhythmias and heart failure. The team aims to explore the mechanisms that regulate late sodium currents, which are linked to these heart diseases. By studying a specific modulator called fibroblast growth factor homologous factor (FHF), the researchers hope to develop new peptide-based inhibitors that can effectively manage these harmful currents. This work involves advanced techniques to assess the molecular interactions and effects on heart cells.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent life-threatening heart conditions caused by abnormal sodium currents.
How similar studies have gone: Previous research has shown promise in targeting sodium currents for cardiac treatment, suggesting that this approach could yield significant advancements.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Johny, Manu Ben — Columbia University Health Sciences
- Study coordinator: Johny, Manu Ben
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.