Understanding how to prevent breast cancer in women at high risk
In vitro models as a window to learn how to change outcomes in women at high risk of developing breast cancer
This study is looking at how to find and focus on certain early cell changes in women who are at high risk for breast cancer, especially those with BRCA1 and BRCA2 gene mutations, to help figure out the best ways to prevent cancer for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10907602 on NIH RePORTER |
What this research studies
This research investigates how to identify and target specific precancerous cell types in women who are at high risk for developing breast cancer, particularly those with inherited mutations in the BRCA1 and BRCA2 genes. By using advanced techniques like organoid culturing and single-cell RNA sequencing, the study aims to create models that can help determine which women would benefit from preventive interventions. The research will analyze breast tissue samples to uncover cellular changes that indicate a higher risk of cancer, ultimately aiming to personalize prevention strategies for these patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include women with BRCA1 or BRCA2 mutations or those identified as high risk based on imaging markers.
Not a fit: Patients without genetic predispositions to breast cancer or those not classified as high risk may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized prevention strategies that significantly reduce the risk of breast cancer in high-risk women.
How similar studies have performed: Other research has shown promise in using similar approaches to identify cancer risk factors, but this specific methodology is relatively novel.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Rosenbluth, Jennifer M. — University of California, San Francisco
- Study coordinator: Rosenbluth, Jennifer M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.