Understanding how to predict treatment responses in sleep apnea patients
Predicting response to non-PAP therapies in OSA using PSG-derived endotypes
This study is looking at how to find out which people with obstructive sleep apnea will do best with different treatments, like special mouthpieces or nerve stimulation, so that everyone can get the most effective care for their sleep issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10903953 on NIH RePORTER |
What this research studies
This research investigates how to better predict which patients with obstructive sleep apnea (OSA) will respond to alternative treatments like mandibular advancement devices (MADs) and hypoglossal nerve stimulation (HGNS). By analyzing data from sleep studies (polysomnography), the researchers aim to identify specific characteristics of OSA that influence treatment success. They will also explore the potential of using targeted medications to improve outcomes for patients who do not respond to these therapies. This approach seeks to personalize treatment options for individuals suffering from OSA.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with obstructive sleep apnea who are considering or have tried alternative treatments like MADs or HGNS.
Not a fit: Patients who have not been diagnosed with obstructive sleep apnea or those who are successfully managed with continuous positive airway pressure (CPAP) therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients with obstructive sleep apnea who do not benefit from standard therapies.
How similar studies have performed: Previous research has shown promise in using polysomnography to identify treatment responses in sleep apnea, suggesting that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Wellman, David Andrew — Brigham and Women's Hospital
- Study coordinator: Wellman, David Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.