Understanding how to normalize brain cell activity after chemical exposure
Project 3: Normalization of Neuronal Excitability
This study is looking at how long-term exposure to certain chemicals can affect the brain and cause problems like seizures and memory issues, and it aims to find ways to identify people who might be at greater risk after a serious exposure, so we can improve treatments and help them feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10911237 on NIH RePORTER |
What this research studies
This research investigates the long-term effects of exposure to organophosphate (OP) chemicals, which can lead to severe neurological issues such as seizures and cognitive dysfunction. The study aims to identify biological markers that can predict which individuals are at higher risk for developing these chronic conditions after experiencing acute OP intoxication. By examining the timing and effectiveness of current treatments, including atropine and benzodiazepines, the research seeks to improve therapeutic strategies and outcomes for affected patients. The approach combines clinical and preclinical data to better understand the underlying mechanisms of neuronal excitability and potential interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced acute organophosphate exposure and are at risk for developing seizures or cognitive impairments.
Not a fit: Patients who have not been exposed to organophosphate chemicals or who do not exhibit symptoms of neurological dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols that prevent long-term neurological damage in patients exposed to harmful chemicals.
How similar studies have performed: Previous research has shown that identifying biological markers can be effective in predicting neurological outcomes in similar contexts, suggesting a promising avenue for this study.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Gurkoff, Gene Gabriel — University of California at Davis
- Study coordinator: Gurkoff, Gene Gabriel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.