Understanding how to maintain weight loss in adults

The Physiology of the Weight Reduced State Data Coordinating Center

NIH-funded research University of Pittsburgh at Pittsburgh · NIH-11085269

This study is looking at how different body factors affect keeping off weight after losing it, and it's for adults who are overweight or obese; participants will get support to help them maintain their weight loss for at least a year while researchers learn what helps people succeed in staying at a healthier weight.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of Pittsburgh at Pittsburgh NIH-funded
Lab location1 site (Pittsburgh, United States)
Project IDNIH-11085269 on NIH RePORTER

What this research studies

This research investigates the physiological factors that influence weight maintenance after weight loss in adults with overweight or obesity. It involves a consortium of clinical centers that will implement behavioral and lifestyle interventions aimed at helping participants achieve and sustain weight loss over a minimum of 12 months. Participants will be monitored longitudinally, and various data and biological samples will be collected to explore the mechanisms behind successful weight maintenance. The goal is to identify individual differences in weight regulation and the factors that contribute to long-term success in maintaining a reduced weight.

Who could benefit from this research

Good fit: Ideal candidates for this research are adults aged 21 and older who are overweight or obese and are seeking to lose weight and maintain that loss.

Not a fit: Patients who are not overweight or obese, or those who are unable to participate in behavioral interventions, may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to more effective strategies for long-term weight management in adults, improving overall health outcomes.

How similar studies have performed: Previous research has shown promise in behavioral interventions for weight loss and maintenance, indicating that this approach has potential for success.

Where this research is happening

Pittsburgh, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.