Understanding how to keep mitochondria healthy
Homeostatic Mechanisms Regulating Mitochondrial Health EQUIPMENT SUPPLEMENT
This study is looking at how our cells keep their energy-producing parts, called mitochondria, healthy and working well, which could help find new treatments for people with conditions caused by mitochondrial problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project ID | NIH-11097132 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that maintain mitochondrial health, which is crucial for cellular energy production and overall human health. It focuses on three key processes: the dynamics of mitochondrial fusion and fission, the selective degradation of damaged mitochondria through mitophagy, and the regulation of mitochondrial biogenesis. By using advanced techniques such as mouse genetics and cell biology, the research aims to fill important knowledge gaps about how these processes work together to ensure proper mitochondrial function. Patients may benefit from insights gained that could lead to new treatments for conditions related to mitochondrial dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions related to mitochondrial dysfunction, such as neurodegenerative diseases or metabolic disorders.
Not a fit: Patients with conditions unrelated to mitochondrial health or those who do not exhibit mitochondrial dysfunction may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for diseases linked to mitochondrial dysfunction, improving patient outcomes.
How similar studies have performed: Other research has shown promising results in understanding mitochondrial dynamics and their implications for health, suggesting that this approach has potential for significant advancements.
Where this research is happening
Pasadena, United States
- California Institute of Technology — Pasadena, United States (Active)
Researchers
- Principal investigator: Chan, David C — California Institute of Technology
- Study coordinator: Chan, David C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.