Understanding how to increase fetal hemoglobin production in sickle cell disease
Regulation of hemoglobin production in normal and disease states
This study is looking at how certain blood cells that make a special type of hemoglobin can be increased in people with sickle cell disease, with the goal of finding new ways to help them produce more of this helpful hemoglobin.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11082321 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind fetal hemoglobin (HbF) production in patients with sickle cell disease (SCD) and healthy adults. It focuses on a specific type of blood cell called F-cells, which produce HbF, and aims to increase both the number of these cells and the amount of HbF they produce. The study employs advanced techniques to analyze the genetic and chromatin characteristics of these cells, comparing them to other blood cells that do not produce HbF. By understanding these differences, the research seeks to identify new therapeutic strategies for enhancing HbF production in SCD patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with sickle cell disease and healthy adults over the age of 21 who are interested in understanding their hemoglobin production.
Not a fit: Patients who do not have sickle cell disease or related hemoglobin disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve the health and quality of life for patients with sickle cell disease.
How similar studies have performed: Previous research has shown promising results in increasing fetal hemoglobin production through various therapeutic approaches, indicating that this area of study has potential for success.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Khandros, Eugene — Children's Hosp of Philadelphia
- Study coordinator: Khandros, Eugene
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.