Understanding how to improve treatment outcomes for Chagas disease
Official title: Treatment outcome requirements for disease prevention in Chagas disease
Funded at University of Georgia · NIH-10780477 · Data updated 2026-11-12
This study is looking at how starting treatment sooner or later for Chagas disease in dogs can help them get better and protect their hearts, and the results could help us understand how to treat the disease in people too.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | August 19, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $646,291 |
| NIH project number | 1R01AI180075-01 |
| Project ID | NIH-10780477 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been recently infected with Trypanosoma cruzi or are at high risk of infection.
✕Less likely to help
Patients who have chronic Chagas disease with significant heart damage may not benefit from this research.
What this research studies
This research investigates the effects of early versus delayed treatment for Chagas disease, caused by the parasite Trypanosoma cruzi. By studying infected dogs in Texas, the project aims to determine how quickly treatment can improve health outcomes and reduce heart damage. The approach includes advanced testing methods to measure treatment success through blood samples and clinical assessments. The findings could provide valuable insights into managing Chagas disease in humans.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols that enhance recovery and reduce complications from Chagas disease.
How similar studies have gone: Previous research has shown promising results in treating Chagas disease with early intervention, suggesting that this approach could be effective.
Where this research is happening
-
University of Georgia
Athens, United States Active
Researchers
- Principal investigator: Tarleton, Rick L — University of Georgia
- Study coordinator: Tarleton, Rick L
Related research
Other NIH-funded projects on the same topics.
-
Treatment outcomes for Chagas disease in dogs to inform human care
This grant tests whether treating early versus later in infection improves recovery and long-term health in dogs with Chagas disease, with findings intended to help people protected from or living with the disease.
-
Gut bacteria and treatment outcomes in lymphoma
Seeing whether the mix of gut bacteria relates to treatment success and immune responses in people with diffuse large B‑cell lymphoma.
-
Suicide risk interventions: comparing how much therapy and brain markers predict outcomes
A study in veterans and active-duty service members compares how different amounts of therapy, plus brain-activity clues, affect future suicide risk.
-
Improving Chagas Disease Treatment
This research explores how quickly treatment for Chagas disease can prevent heart damage and provide lasting protection.
-
Blood markers in teens to detect suicide risk and predict treatment response
Researchers are measuring tiny RNA fragments in blood exosomes to find signals of suicide risk and treatment response in adolescents.
-
Comparing different treatment approaches for preventing suicide in veterans and active duty service members
This study is looking at different types of support to help active duty service members and veterans who are at risk of suicide, comparing a quick one-time therapy session with longer treatments to see which works best for different people.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.