Understanding how to improve tissue regeneration in adults
Official title: DISARMing the immunological barriers to regeneration in mammals
Funded at Jackson Laboratory · NIH-11010420 · Data updated 2026-11-12
This study is looking at how the immune system affects the body's ability to heal and regrow tissues, using mice to see how different areas of tissue removal impact healing, with the hope of finding ways to help people heal better after injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $485,286 |
| NIH project number | 5R01HD110440-03 |
| Project ID | NIH-11010420 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who have experienced tissue damage or amputations and are seeking improved healing options.
✕Less likely to help
Patients with conditions that do not involve tissue damage or those who are not adults may not benefit from this research.
What this research studies
This research aims to explore the mechanisms that limit tissue regeneration in adult mammals, particularly focusing on the immune system's role in this process. By using a mouse model that mimics human limb anatomy, the researchers will investigate how different locations of tissue removal affect regeneration. Advanced imaging techniques, such as high-resolution 3D imaging, will be employed to assess the regeneration of bone and soft tissues. The ultimate goal is to identify ways to enhance the body's natural ability to regenerate damaged tissues, which could lead to improved healing outcomes for patients.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in regenerative medicine, allowing for better healing of injuries and potentially reducing the need for surgical interventions.
How similar studies have gone: While the study of regeneration in mammals is ongoing, the specific approach of targeting immune mechanisms for enhancing regeneration is relatively novel and has not been extensively tested.
Where this research is happening
-
Jackson Laboratory
Bar Harbor, United States Active
Researchers
- Principal investigator: Godwin, James W — Jackson Laboratory
- Study coordinator: Godwin, James W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.