Understanding how to improve tissue regeneration in adults
DISARMing the immunological barriers to regeneration in mammals
['FUNDING_R01'] · JACKSON LABORATORY · NIH-11010420
This study is looking at how the immune system affects the body's ability to heal and regrow tissues, using mice to see how different areas of tissue removal impact healing, with the hope of finding ways to help people heal better after injuries.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JACKSON LABORATORY (nih funded) |
| Locations | 1 site (BAR HARBOR, UNITED STATES) |
| Trial ID | NIH-11010420 on ClinicalTrials.gov |
What this research studies
This research aims to explore the mechanisms that limit tissue regeneration in adult mammals, particularly focusing on the immune system's role in this process. By using a mouse model that mimics human limb anatomy, the researchers will investigate how different locations of tissue removal affect regeneration. Advanced imaging techniques, such as high-resolution 3D imaging, will be employed to assess the regeneration of bone and soft tissues. The ultimate goal is to identify ways to enhance the body's natural ability to regenerate damaged tissues, which could lead to improved healing outcomes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have experienced tissue damage or amputations and are seeking improved healing options.
Not a fit: Patients with conditions that do not involve tissue damage or those who are not adults may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in regenerative medicine, allowing for better healing of injuries and potentially reducing the need for surgical interventions.
How similar studies have performed: While the study of regeneration in mammals is ongoing, the specific approach of targeting immune mechanisms for enhancing regeneration is relatively novel and has not been extensively tested.
Where this research is happening
BAR HARBOR, UNITED STATES
- JACKSON LABORATORY — BAR HARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GODWIN, JAMES W — JACKSON LABORATORY
- Study coordinator: GODWIN, JAMES W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.