Understanding how to improve organ transplant success by regulating immune responses
Official title: Studying and regulating trained immunity in mouse transplant models
Funded at Icahn School of Medicine at Mount Sinai · NIH-11064095 · Data updated 2026-11-12
This study is looking at ways to help the immune system accept transplanted organs without needing lifelong medication to suppress it, which could make organ transplants safer and easier for patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $919,879 |
| NIH project number | 5P01AI168258-03 |
| Project ID | NIH-11064095 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have received or are considering organ transplants, particularly for organs like the heart or lungs.
✕Less likely to help
Patients who are not candidates for organ transplantation or those with conditions unrelated to transplant rejection may not benefit from this research.
What this research studies
This research investigates how the immune system can be trained to accept transplanted organs without the need for long-term immunosuppressive therapy. By studying mouse models, the researchers aim to identify mechanisms that lead to better tolerance of transplanted organs, particularly focusing on differences between various organ types. The approach involves examining how certain organs can promote tolerance in others and how trained immunity affects the rejection of transplants. This could lead to new therapies that enhance graft survival and reduce side effects for patients.
Why it matters
Potential benefit: If successful, this research could lead to improved organ transplant outcomes, allowing patients to live without the burdens of chronic immunosuppression.
How similar studies have gone: Previous research has shown promise in understanding organ tolerance, but this specific approach focusing on trained immunity in transplantation is relatively novel.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Teunissen, Abraham — Icahn School of Medicine at Mount Sinai
- Study coordinator: Teunissen, Abraham
Related research
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-
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.