Understanding how to improve muscle recovery in older adults after inactivity
Elucidating the Mechanisms of Translational Approaches to Enhance Recovery of Aged Muscle
This study is looking at how a mix of metformin and leucine can help older adults recover their muscle strength after being inactive for a while, using tests on older mice to find out how this treatment works and how it might help people bounce back after surgery or long periods of not moving.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10928223 on NIH RePORTER |
What this research studies
This research investigates the effects of a combination treatment of metformin and leucine on muscle recovery in older adults who have experienced muscle atrophy due to physical inactivity. The study uses pre-clinical trials with aged mice to explore how this treatment can enhance muscle strength and reduce muscle damage. By examining the underlying mechanisms of how these compounds work together, the research aims to develop effective strategies for improving muscle health and function in older populations. The ultimate goal is to translate these findings into potential therapies that could benefit older adults recovering from surgery or prolonged inactivity.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who have experienced muscle loss due to inactivity, such as after surgery or during extended periods of physical immobility.
Not a fit: Patients who are not experiencing muscle atrophy or who have other underlying health conditions that prevent participation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve muscle recovery and overall health in older adults.
How similar studies have performed: Previous research has shown promising results with similar approaches using metformin and leucine for muscle recovery, indicating potential for success in this area.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Petrocelli, Jonathan Joseph — Dana-Farber Cancer Inst
- Study coordinator: Petrocelli, Jonathan Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.