Understanding how to improve insulin-producing cells for diabetes treatment
Official title: Identification of Novel Regulatory Mechanisms Driving Human beta-Cell Maturation and Function.
Funded at Icahn School of Medicine at Mount Sinai · NIH-11043389 · Data updated 2026-11-12
This study is looking at how insulin-producing cells in the pancreas develop and work, with the hope of finding better treatments for Type 1 Diabetes, so that patients can manage their condition more effectively.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $169,000 |
| NIH project number | 5R03DK138492-02 |
| Project ID | NIH-11043389 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Type 1 Diabetes, particularly those who are 21 years old or younger.
✕Less likely to help
Patients with Type 2 Diabetes or those who do not have diabetes may not receive any benefit from this research.
What this research studies
This research investigates the mechanisms that control the maturation and function of insulin-producing beta cells in the pancreas, which are crucial for managing Type 1 Diabetes (T1D). By utilizing advanced techniques like CRISPR and chromatin accessibility assays, the study aims to identify specific genes and regulatory elements that influence the development of these cells. The goal is to enhance the production and regulation of insulin from stem cell-derived beta cells, potentially leading to better treatments for T1D. Patients may benefit from insights that could lead to more effective therapies and improved management of their condition.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Type 1 Diabetes by improving the functionality of insulin-producing cells.
How similar studies have gone: Other research has shown promise in using similar approaches to enhance beta cell function, indicating potential for success in this area.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Bevacqua, Romina — Icahn School of Medicine at Mount Sinai
- Study coordinator: Bevacqua, Romina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.