Understanding how to improve insulin function to manage diabetes
Regulating SNARE mechanisms to remediate glucose homeostasis
['FUNDING_R01'] · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · NIH-10677652
This study is looking at how a protein called STX4 can help people with type 2 diabetes and prediabetes by improving how their bodies release and respond to insulin, with the goal of finding new ways to better manage blood sugar levels.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BECKMAN RESEARCH INSTITUTE/CITY OF HOPE (nih funded) |
| Locations | 1 site (DUARTE, UNITED STATES) |
| Trial ID | NIH-10677652 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which a protein called STX4 can be used to improve insulin secretion and sensitivity in patients with type 2 diabetes (T2D) and prediabetes. The study focuses on how dysfunction in pancreatic cells and skeletal muscle contributes to these conditions, and aims to manipulate STX4 signaling to prevent or reverse the effects of diabetes. By exploring these cellular processes, the research seeks to develop new therapeutic strategies for managing blood glucose levels effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 2 diabetes or prediabetes, particularly those experiencing insulin resistance.
Not a fit: Patients with type 1 diabetes or those whose diabetes is not related to insulin resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help manage or even reverse type 2 diabetes and prediabetes.
How similar studies have performed: Previous research has shown promising results in manipulating cellular mechanisms to improve insulin function, indicating potential for success in this approach.
Where this research is happening
DUARTE, UNITED STATES
- BECKMAN RESEARCH INSTITUTE/CITY OF HOPE — DUARTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: THURMOND, DEBBIE C — BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
- Study coordinator: THURMOND, DEBBIE C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.