Understanding how to improve CAR T cell therapy for children with certain cancers
Defining Pre-treatment Correlates of Patient GD2 CAR T Cell Exhaustion and Memory Using Multi-Dimensional Immune Profiling
['FUNDING_CAREER'] · STANFORD UNIVERSITY · NIH-10828387
This study is looking into why CAR T cell therapy sometimes doesn't work as well for kids and young adults with tough-to-treat tumors, and it hopes to find ways to make these treatments more effective so that patients can have better outcomes.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10828387 on ClinicalTrials.gov |
What this research studies
This research investigates the challenges faced by CAR T cell therapy in treating children and young adults with metastatic or relapsed solid tumors. It focuses on understanding why CAR T cells may become exhausted and lose their effectiveness after treatment. By analyzing patient samples using advanced technologies, the study aims to identify factors that influence CAR T cell performance, such as the type of costimulatory signals used and prior chemotherapy exposure. The goal is to enhance the memory potential of CAR T cells, which could lead to better treatment outcomes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and young adults diagnosed with metastatic or relapsed solid tumors who are considering CAR T cell therapy.
Not a fit: Patients with hematologic malignancies or those who are not eligible for CAR T cell therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective CAR T cell therapies for children with solid tumors, improving their chances of recovery.
How similar studies have performed: Previous research has shown promise in enhancing CAR T cell effectiveness through various modifications, indicating that this approach could yield valuable insights.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAMAKRISHNA, SNEHA — STANFORD UNIVERSITY
- Study coordinator: RAMAKRISHNA, SNEHA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.