Understanding how to improve bone growth and healing
Official title: Regulation of Skeletal Growth and Regeneration
Funded at Children's Hosp of Philadelphia · NIH-11045204 · Data updated 2026-11-12
This study is looking at how bones grow and heal in kids, especially focusing on the growth plates that help bones develop, to find ways to improve healing for those with injuries or bone problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $378,250 |
| NIH project number | 1R01AR083903-01A1 |
| Project ID | NIH-11045204 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children with growth plate injuries, genetic conditions affecting bone growth, or those experiencing side effects from medications that impact skeletal development.
✕Less likely to help
Patients with fully developed skeletons or those without skeletal growth issues may not benefit from this research.
What this research studies
This research focuses on the mechanisms that regulate skeletal growth and regeneration, particularly in children. It investigates how growth plates, which are crucial for bone development, function and how they can be affected by injuries, genetic disorders, or medications. By studying the cellular and molecular processes involved, the research aims to identify potential therapeutic targets to enhance bone healing and growth in affected individuals. The research will involve both laboratory studies and potential clinical applications to improve outcomes for patients with skeletal issues.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve bone growth and healing in children with skeletal disorders or injuries.
How similar studies have gone: Previous research has shown promising results in understanding skeletal growth mechanisms, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Pacifici, Maurizio — Children's Hosp of Philadelphia
- Study coordinator: Pacifici, Maurizio
Related research
Other NIH-funded projects on the same topics.
-
Emotional and biobehavioral links in parent-infant closeness
A program to understand how parent and baby feel and react to each other in early life, with the goal of guiding better child social and emotional development.
-
Leukodystrophy Clinical Careers and Mentorship Network
A program to train, mentor, and support clinicians and researchers to advance care for people with leukodystrophies.
-
Role of ATP1A3 mutations in sudden death related to epilepsy
Aims to understand how ATP1A3 gene changes may lead to sudden death in kids with epilepsy and is exploring new ways to prevent it.
-
Kids First Data Resource Center: cloud-enabled data sharing for childhood cancer research
A data resource project that makes pediatric cancer data and analyses more accessible to researchers, with the goal of advancing understanding and care for children with cancer.
-
PROMISE: A Network for Real-World Evidence in Rare Pediatric Cancers
A network will collect and harmonize pediatric cancer patient records from multiple centers to create high-quality real-world data that can support quicker, regulatory-ready insights when randomized trials aren’t feasible.
-
Data Hub Core for Down syndrome research
A data hub project is building a big, interoperable platform to securely share and analyze information from people with Down syndrome and related conditions.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.