Understanding how to improve blood flow in diabetic skin wounds
Official title: Regulatory Mechanisms Addressing Diabetic Vasculopathy
Funded at University of Pittsburgh at Pittsburgh · NIH-10900604 · Data updated 2026-11-12
This study is looking at how to improve blood flow and healing in chronic skin wounds caused by diabetes by testing a new treatment that combines different therapies, which could help people with diabetic ulcers heal better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | August 7, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $367,157 |
| NIH project number | 5R01DK136814-02 |
| Project ID | NIH-10900604 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who suffer from diabetic ulcers or chronic skin wounds.
✕Less likely to help
Patients with non-diabetic wounds or those who do not have chronic skin conditions may not benefit from this research.
What this research studies
This research investigates the mechanisms that lead to poor blood flow in chronic skin wounds caused by diabetes. It focuses on developing a combined gene therapy approach that delivers multiple angiogenic molecules to enhance healing. By examining the role of lipid mediators in supporting blood vessel growth, the study aims to improve the effectiveness of existing therapies like VEGF. Patients with diabetic ulcers may benefit from new treatment strategies that address the underlying issues of blood flow and healing.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for diabetic ulcers, significantly improving healing outcomes for patients.
How similar studies have gone: Previous research has shown promise in using combined gene therapies for improving wound healing, suggesting that this approach could be effective.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Singh, Kanhaiya — University of Pittsburgh at Pittsburgh
- Study coordinator: Singh, Kanhaiya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.