Understanding how to help the retina heal itself
Epigenetic Regulation of Retinal Regeneration
['FUNDING_R01'] · UNIVERSITY OF TEXAS AT AUSTIN · NIH-11001583
This study is looking at how certain cells in the eye can help heal damaged retina tissue, using zebrafish as a model since they can fully regenerate their retinas, and the goal is to find ways to apply this knowledge to develop new treatments for people with retinal diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS AT AUSTIN (nih funded) |
| Locations | 1 site (AUSTIN, UNITED STATES) |
| Trial ID | NIH-11001583 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind retinal regeneration, particularly focusing on how certain cells in the retina, called Müller glia, can be stimulated to regenerate damaged retinal tissue. By studying zebrafish, which can fully regenerate their retinas, researchers aim to uncover the molecular processes that allow this regeneration to occur. The study will explore the role of specific genes and epigenetic changes that could potentially be manipulated to enhance regenerative responses in mammals, including humans. Patients may benefit from insights that could lead to new treatments for degenerative retinal diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from degenerative retinal diseases or those at risk of retinal damage.
Not a fit: Patients with non-degenerative eye conditions or those without retinal damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that restore vision in patients with retinal damage.
How similar studies have performed: Previous studies have shown promising results in using similar approaches to stimulate retinal regeneration in animal models, indicating potential for success in human applications.
Where this research is happening
AUSTIN, UNITED STATES
- UNIVERSITY OF TEXAS AT AUSTIN — AUSTIN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GROSS, JEFFREY — UNIVERSITY OF TEXAS AT AUSTIN
- Study coordinator: GROSS, JEFFREY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.