Understanding how to fix defects in the aortic arch artery
Identification of compensatory mechanisms to rescue aortic arch artery defects
['FUNDING_R01'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-11055967
This study is looking at how the aortic arch artery forms and what goes wrong in babies with 22q11 deletion syndrome, hoping to find ways to help improve heart development and treat congenital heart issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-11055967 on ClinicalTrials.gov |
What this research studies
This research investigates the development of the aortic arch artery, which is crucial for proper blood circulation from the heart. It focuses on identifying genetic mechanisms that lead to defects in this artery, particularly in infants with 22q11 deletion syndrome, a common chromosomal abnormality. By using innovative mouse models, the study aims to uncover how certain progenitor cells can compensate for deficiencies in the artery's development. This could lead to new insights into congenital heart disease and potential therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants diagnosed with 22q11 deletion syndrome or those exhibiting aortic arch artery defects.
Not a fit: Patients without congenital heart defects or those not affected by 22q11 deletion syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for congenital heart defects, improving outcomes for affected infants.
How similar studies have performed: Previous research has shown promise in understanding compensatory mechanisms in other congenital conditions, suggesting potential for success in this novel approach.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ASTROF, SOPHIE — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: ASTROF, SOPHIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: 22q11 Chromosomal Microdeletion Syndrome, 22q11 Deletion Syndrome, 22q11.2 deletion syndrome