Understanding how to fix brain changes caused by opioid addiction
Novel mechanisms for correcting opioid-induced synaptic abnormalities
This study is looking at how opioid addiction changes the brain and causes cravings, and it’s testing a medication called acetazolamide to see if it can help reduce those cravings and support recovery for people dealing with opioid addiction.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11083725 on NIH RePORTER |
What this research studies
This research investigates the long-lasting changes in brain synapses caused by opioid addiction, focusing on how these changes contribute to drug cravings and relapse. The team will explore the role of acid-sensing ion channels and carbonic anhydrase 4 in reversing these synaptic alterations. By using a medication called acetazolamide, the researchers aim to enhance the activity of these channels, potentially leading to reduced cravings and improved recovery outcomes for individuals struggling with opioid addiction. The study will involve rigorous assessments of both brain function and behavior in response to opioid exposure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are experiencing opioid addiction or have recently undergone opioid withdrawal.
Not a fit: Patients who are not currently struggling with opioid addiction or who have not experienced opioid withdrawal may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce cravings and prevent relapse in individuals recovering from opioid addiction.
How similar studies have performed: Other research has shown promise in targeting synaptic changes in addiction, but this specific approach using acetazolamide is relatively novel.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Wemmie, John a — University of Iowa
- Study coordinator: Wemmie, John a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.