Understanding how to create specific heart cells from stem cells
Patterning myocardial specification of human pluripotent stem cells
This study is exploring how to turn special stem cells into specific heart cells to help us better understand heart diseases and create new treatments, making it easier to test new drugs and therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10638342 on NIH RePORTER |
What this research studies
This research investigates how to direct human pluripotent stem cells to develop into specific types of heart cells, which are crucial for understanding heart diseases and developing new treatments. By manipulating a signaling molecule called retinoic acid, the researchers aim to produce more uniform populations of heart cells that can be used for drug testing and potential therapies. The study focuses on overcoming current challenges in generating these cells, which often result in a mixed population that is not suitable for clinical applications. If successful, this approach could lead to better models for studying heart conditions and more effective treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with heart conditions or those at risk of developing heart diseases.
Not a fit: Patients with non-cardiac conditions or those who do not have any heart-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide more effective heart cell therapies and improve drug testing for heart diseases.
How similar studies have performed: Previous research has shown promise in using stem cells for cardiac applications, indicating that this approach could lead to significant advancements.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Cho, Hee Cheol — Johns Hopkins University
- Study coordinator: Cho, Hee Cheol
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.