Understanding how to create blood stem cells from human stem cells
Official title: Characterization of multilineage definitive hematopoietic progenitors from human pluripotent stem cells
Funded at Icahn School of Medicine at Mount Sinai · NIH-11045767 · Data updated 2026-11-12
This study is looking at how to turn special stem cells from humans into blood cells in the lab, which could help people who need new blood cells, like those with certain blood disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $538,989 |
| NIH project number | 5R01HL172940-02 |
| Project ID | NIH-11045767 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be adults over 21 years old who may require blood cell therapies.
✕Less likely to help
Patients with conditions unrelated to blood cell production or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on deriving hematopoietic stem cells (HSCs), which are essential for producing all types of blood cells, from human pluripotent stem cells (hPSCs) in a laboratory setting. The team is investigating the specific signals and conditions needed to successfully differentiate these stem cells into functional blood cell progenitors. By employing a novel approach that utilizes retinoic acid signaling, they aim to create cells that can effectively migrate to bone marrow and develop into various blood cell types. The research will also explore the genetic factors involved in this process to enhance the potential for cell replacement therapies.
Why it matters
Potential benefit: If successful, this research could lead to advanced therapies for blood-related disorders by providing a reliable source of blood stem cells.
How similar studies have gone: Previous research has shown promise in deriving blood stem cells from pluripotent stem cells, indicating that this approach has potential for success.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Sturgeon, Christopher Michael — Icahn School of Medicine at Mount Sinai
- Study coordinator: Sturgeon, Christopher Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.