Understanding how to control TH17 cells in autoimmune diseases
Control of the Survival Pathways in TH17 Cells
['FUNDING_R21'] · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · NIH-11035988
This study is looking at how certain immune cells called TH17 cells contribute to conditions like asthma and autoimmune diseases, and it aims to find new ways to help turn off these cells to reduce their harmful effects.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR (nih funded) |
| Locations | 1 site (ALBUQUERQUE, UNITED STATES) |
| Trial ID | NIH-11035988 on ClinicalTrials.gov |
What this research studies
This research investigates the role of TH17 cells, which are involved in various inflammatory and autoimmune diseases. The focus is on understanding how to activate death pathways in these cells to potentially reduce their pathogenic effects. The researchers will explore non-steroid pathways that influence TH17 cell survival and function, particularly through the activation of specific cytokines and signaling pathways. By targeting these pathways, the goal is to develop new therapeutic strategies for conditions like asthma and other autoimmune disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autoimmune diseases such as asthma or atrophic arthritis, particularly those who have not responded well to existing treatments.
Not a fit: Patients with autoimmune conditions that do not involve TH17 cells or those who are not experiencing significant symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from autoimmune diseases by effectively controlling TH17 cell activity.
How similar studies have performed: While there have been promising approaches targeting TH17 cells, this specific investigation into the IRE1 and STAT3 pathways represents a novel exploration in the field.
Where this research is happening
ALBUQUERQUE, UNITED STATES
- UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR — ALBUQUERQUE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, XUEXIAN — UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
- Study coordinator: YANG, XUEXIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.