Understanding how to block chitin production in harmful fungi
Catalysis and inhibition of chitin synthesis from pathogenic fungi
This study is looking at how to create new antifungal medicines that can specifically target harmful fungi like Candida albicans, which can cause infections, while keeping our healthy cells safe.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11089613 on NIH RePORTER |
What this research studies
This research investigates the inhibition of chitin synthases, which are crucial for the survival of pathogenic fungi like Candida albicans. By focusing on the structural and mechanistic aspects of these enzymes, the research aims to develop antifungal agents that can selectively target these fungi without harming human cells. The approach involves studying the interactions between these enzymes and potential antifungal compounds to enhance their effectiveness. If successful, this could lead to new treatments for invasive fungal infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with invasive fungal infections, particularly those caused by Candida albicans.
Not a fit: Patients with fungal infections caused by non-Candida species or those who do not respond to antifungal treatments may not benefit from this research.
Why it matters
Potential benefit: This research could lead to the development of more effective antifungal treatments with fewer side effects for patients suffering from fungal infections.
How similar studies have performed: Previous research has shown promise in targeting chitin synthases for antifungal therapy, indicating that this approach could be effective.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Yokoyama, Kenichi — Duke University
- Study coordinator: Yokoyama, Kenichi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.