Understanding how to achieve a functional cure for hepatitis B in people with HIV.
Mechanisms of HBV Functional Cure During Tenofovir-based ART in HIV/HBV Coinfection
This study is looking at how to help people with both chronic hepatitis B and HIV get better by understanding their immune responses while they are on a specific treatment, so if you're living with these conditions, your participation could help find new ways to improve care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10684739 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind achieving a functional cure for chronic hepatitis B virus (HBV) infection in individuals who are also infected with HIV. The study focuses on patients undergoing tenofovir-based antiretroviral therapy and aims to understand the immune responses that contribute to the loss of hepatitis B surface antigen (HBsAg). By analyzing a cohort of HIV-HBV coinfected individuals, the research seeks to identify factors that enhance the effectiveness of current treatments and explore new therapeutic options. Participants will be monitored for their immune responses and liver health over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who are coinfected with HIV and hepatitis B virus and are currently receiving tenofovir-based therapy.
Not a fit: Patients who are not infected with hepatitis B or those who are not receiving tenofovir-based therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that enable a functional cure for hepatitis B in patients with HIV.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in HBV infection, but this specific approach in HIV-HBV coinfection is relatively novel.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Vinikoor, Michael Jeffrey — University of Alabama at Birmingham
- Study coordinator: Vinikoor, Michael Jeffrey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.