Understanding how TNF affects B cell tolerance in autoimmune conditions
The Role of TNF in Breaking B Cell Tolerance
This study is looking at how a protein called TNF affects B cells, which are important for our immune system, to help understand why some people develop autoimmune diseases, with the hope of creating better, personalized treatments for those affected.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project ID | NIH-10866557 on NIH RePORTER |
What this research studies
This research investigates the role of TNF (tumor necrosis factor) in breaking the tolerance of B cells, which are crucial for immune response. By combining studies in mice and humans, the research aims to uncover mechanisms that lead to autoimmune diseases. The findings could help in developing personalized medicine approaches for patients suffering from these conditions. Dr. Quach, the principal investigator, is focused on enhancing her skills as a systems immunologist to better understand and treat autoimmune disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autoimmune diseases who may benefit from targeted therapies.
Not a fit: Patients without autoimmune conditions or those who do not have a response to TNF-related therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective personalized treatments for patients with autoimmune diseases.
How similar studies have performed: Previous research has shown promising results in understanding TNF's role in autoimmune diseases, indicating that this approach has potential for success.
Where this research is happening
Manhasset, United States
- Feinstein Institute for Medical Research — Manhasset, United States (Active)
Researchers
- Principal investigator: Quach, Tam D — Feinstein Institute for Medical Research
- Study coordinator: Quach, Tam D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.