Understanding how TMEM184B affects brain function and maintenance
Establishing the Function of TMEM184B in mTORC1 Regulation and Synaptic Maintenance
This study is looking at how a protein called TMEM184B helps keep brain connections working well, which is important for good brain health, and it aims to find out how changes in the TMEM184B gene might be linked to neurological disorders, so that patients can better understand their conditions and possible treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-10991831 on NIH RePORTER |
What this research studies
This research investigates the role of the TMEM184B protein in maintaining synaptic structure and function, which is crucial for healthy brain activity. By examining how variations in the TMEM184B gene affect neuronal signaling pathways, the study aims to uncover mechanisms that lead to neurological disorders. The approach includes analyzing the impact of these genetic variations on synaptic transmission and behavior, potentially providing insights into treatment strategies for related conditions. Patients may benefit from a better understanding of their neurological issues linked to TMEM184B.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with neurological disorders such as microcephaly, intellectual disability, corpus callosum hypoplasia, or epilepsy linked to TMEM184B genetic variations.
Not a fit: Patients without any known genetic disruptions in TMEM184B or those with unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for neurological disorders associated with TMEM184B disruptions.
How similar studies have performed: While the specific role of TMEM184B has not been extensively tested, similar research on synaptic proteins has shown promise in understanding and treating neurological disorders.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Bhattacharya, Martha Ruth Chase — University of Arizona
- Study coordinator: Bhattacharya, Martha Ruth Chase
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.