Understanding how TMEM106B genetics affects Alzheimer's and related diseases
Official title: Investigating the role of TMEM106b genetics and pathology in Alzheimer’s disease, LATE and FTLD
Funded at Mayo Clinic Jacksonville · NIH-10933523 · Data updated 2026-11-12
This study is looking at how a specific gene called TMEM106B might affect the risk and progression of Alzheimer's disease and frontotemporal lobar degeneration, and it’s for people who want to understand more about the genetic factors behind these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | September 22, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $1,064,348 |
| NIH project number | 5R01NS132330-02 |
| Project ID | NIH-10933523 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include individuals diagnosed with Alzheimer's disease, frontotemporal lobar degeneration, or amyotrophic lateral sclerosis, particularly those with specific genetic markers.
✕Less likely to help
Patients with neurodegenerative disorders not associated with TMEM106B genetics may not receive benefit from this research.
What this research studies
This research investigates the role of the TMEM106B gene in various neurodegenerative disorders, particularly Alzheimer's disease and frontotemporal lobar degeneration. By examining genetic variants and their impact on protein accumulation in the brain, the study aims to uncover how these factors contribute to disease risk and progression. Patients will be assessed for specific genetic markers, and their brain samples may be analyzed to identify the presence of TMEM106B filaments. This approach could lead to a better understanding of the underlying mechanisms of these diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for patients with Alzheimer's and related neurodegenerative conditions.
How similar studies have gone: Previous research has shown promising results in understanding the role of genetic factors in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Petrucelli, Leonard — Mayo Clinic Jacksonville
- Study coordinator: Petrucelli, Leonard
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.