Understanding how TLT-1 protein works in platelets
Official title: TLT-1 intracellular function
Funded at Oakland University · NIH-10974515 · Data updated 2026-11-12
This study is looking at a protein called TLT-1 in platelets to understand how it helps with blood clotting, which could lead to better treatments for people who have issues with blood coagulation and inflammation.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oakland University NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $434,658 |
| NIH project number | 1R15HL175494-01 |
| Project ID | NIH-10974515 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with conditions related to blood coagulation disorders or those at risk of thrombosis.
✕Less likely to help
Patients who do not have issues related to blood clotting or coagulation may not benefit from this research.
What this research studies
This research investigates the role of TLT-1, a protein found in platelets, in the activation process that leads to blood clotting. The study aims to identify specific sites on the TLT-1 protein that are important for its function and to understand how it is regulated within platelets. By exploring these mechanisms, the research seeks to find ways to control blood clotting without causing excessive bleeding, which could improve treatment options for various conditions related to blood coagulation and inflammation.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that manage blood clotting more effectively, reducing the risk of bleeding complications.
How similar studies have gone: Previous research has shown promise in targeting platelet proteins for therapeutic purposes, suggesting that this approach could yield beneficial results.
Where this research is happening
-
Oakland University
Rochester, United States Active
Researchers
- Principal investigator: Washington, a. Valance — Oakland University
- Study coordinator: Washington, a. Valance
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.